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Consistent reduction in major cardiovascular events, even beyond glycaemic effects Meaningful kidney protection, slower eGFR decline & reduced albuminuria Benefits across phenotypes: diabetes, obesity, HFpEF, CKD & ASCVD A clear shift from organ-specific treatment to system-level risk reduction The next phase feels less about whether these agents work & more about who benefits most, when to start & how to integrate them alongside SGLT2 inhibitors and standard CV therapies

Some patients find that drinking fluids between meals rather than with meals helps minimize the sensation of fullness and associated nausea

One source says you need a prescription letter notarized in triplicate

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Neither choice is a failure