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In the SKOV-3 cell line extending the BSO pretreatment period to 48 h from 24 h marginally reduced the cytotoxicity of cisplatin, whereas the cytotoxicity of the other three drugs remained similar to that observed after 24 h BSO pretreatment
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Compared with the placebo group, the probiotic treatment group did not experience a reduction in Candida counts over time but showed a decrease in the gingival index, OLP severity score and lower VAS scores compared to those of the placebo group 142
Additional investigations suggest a possible connection between NNMT inhibition and cancer biology